Introduction: The effect of exercise on the expression of genes affecting cardiac hypertrophy is unclear. Evidence suggests that some miRNAs play an important role in improving heart function. The aim of this study was to evaluate the response of miR-133a and some markers of cardiac hypertrophy to endurance training. Methods and Materials: To implementation of this experimental research, 10 male Wistar Rats (4-6 weeks old) randomly were divided into 2 groups control and endurance training. Endurance training performed 5 days a week at a speed of 25 m/min and a gradient of zero degrees for 12 weeks. The expression of miR-133a, IGF-1 and IGF-R genes were measured by Real Time PCR. Data were analyzed by independent t-test at the P<0. 05. Results: The results showed that after 12 weeks of aerobic exercise the expression of MiR-133a and IGF-1 gene was significantly higher in the exercise group than in the control group (P=0. 001). Also, after 12 weeks of aerobic training, no significant difference was observed in IGF-R gene expression between the two groups (P <0. 05). Conclusion: According to the findings of the present study, twelve weeks of aerobic exercise may possibly increase cardiac protection activities through cardiac hypertrophy indices.

Background and Aim: The purpose of this study was to determine the frequency of EGFR marker expression in oral Squamous Cell Carcinoma (SCC) and correlative factors.Materials and Methods: A descriptive study was conducted on 40 paraffin embedded blocks of oral SCC. Immunohistochemical staining (IHC) was done for EGFR and EGFR expression was evaluated on the basis of extent and intensity of EGFR immunolabeling in tumor cell membranes. Classification was done on a four point scale as follows: 0 (no labeling, or labeling in <10% of tumor cells); 1 (weak labeling, homogeneous or patchy, in ≤10% of tumor cells); 2 (moderate labeling, homogeneous or patchy, in> 10% of tumor cells); 3 (intense labeling, homogeneous or patchy in >10% of tumor cells). These categories were subsequently grouped into two wider categories for data analysis: absent/weak labeling (0 or 1) and moderate/intense labeling (2 or 3).The data was analyzed by Fisher exact test.Results: The high expression was shown in 45% of OSCCs. There was significant correlation among gender with EGFR expression (p=0.02).Conclusion: In this study EGFR expression was significantly higher in female than male, that can be impress biological behavior of tumor.

Background & Aim: Squamous cell carcinoma is the most common cancer in oral cavity with aggressive behavior. Many researches are done about pathogenesis and detection methods for this cancer. The purpose this research is the evaluation of the length of telomere in oral squamous cell carcinoma (OSCC) and its probably diagnostic value.Materials & Methods: We used the sensitive PCR technique based on primer extension method to determine the telomere length. The procedure steps were 1) DNA isolation 2) PCR assay 3) Electrophoresis for assessment of the PCR products 4) AgN03 staining. At last length of the telomere was determined in comparison with 1Kb marker.Results: In 5 cases of OSCC the telomere length was less than 5Kb and in the other 5 samples it was between 5-5.5Kb, but in all normal tissue samples length of the telomere was more than 5.5Kb (9.4-10.6Kb). The findings showed a significant statistical difference between two groups (P<0.01). Also with the more severe dysplastic changes, higher telomere shortening was seen.Conclusion: Telomere length is shortened is shortened in OSCC compare with normal tissue and can be a useful marker for diagnostic aims.

Background: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors. This study aimed to evaluate the relevance of vascular endothelial growth factor (VEGF) and cytokeratin 19 (CK19) genes as biomarkers for diagnosis of OSCC. Methods: In this study, 30 patients and 30 healthy individuals were selected. CK19 and VEGF were measured in peripheral blood using real-time polymerase chain reaction (PCR) technique. T-test was performed to analyze the data. Findings: In patients with OSCC, CK19 and VEGF markers were positive in 17 and 23 patients out of 30. Conclusion: The expression of VEGF and CK19 is more among the patients with OSCC, compared to healthy people. In summary, the result of this study can be considered as a diagnostic screening test in the early stages of the disease.

Background: There are several types of carcinoma which may cause serious diseases in humans and lead to their death. Neoplasia in squamous cells is a subtype of carcinoma which can cause squamous cell carcinoma (SCC). SCC can occur in several areas in the oral cavity (oral squamous cell carcinoma, OSCC) and cutaneous tissues (cutaneous squamous cell carcinoma, CSCC) such as skin. This study aims to investigate the expression level of cyclin D1 and its relevance to different prognoses of OSCC and CSCC. The present study investigates the expression of cyclin D1 and its relevance to different prognoses of OSCC and CSCC. Indexes such as lesion site, gender, and age have been checked. Methods: In this cross-sectional descriptive-analytical study, 23 cases of OSCC and 23 cases of CSCC were evaluated. The immunohistochemistry (IHC) staining method was employed to study the correlation of cyclin D1 and the above-mentioned SCCs. The data were analyzed using KAI2, Fisher’, s exact test, MannWhitney U test, and dependent t tests in SPSS version 22. 0. Statistical significance was set at P < 0. 05. Results: The results showed that staining status was not significantly correlated with lesion site (P = 0. 999). According to the results, there was no significant relationship between staining pattern and lesion site (P = 0. 749). There was a significant relationship between the severity of staining and lesion site (P = 0. 040). In addition, those with skin lesions showed higher staining intensity. The staining status of gender or age groups was not affected by the adjustment of lesion site. By moderating the effect of lesion site and age group, gender was found to affect staining pattern (P = 0. 036). The odds ratio of having a diffuse pattern was 4. 90 times higher in men than in women. Regardless of the independent variables in the model of people with color intensity 2, their likelihood of going to color 4 was significantly higher (P < 0. 001). People in intensity 0 were significantly less likely to go to 4 (P = 0. 001). People in intensity 1 had no significant relationship with those in intensity 4 (P = 0. 405). Men were less likely to go higher than women. Furthermore, people aged 72 and under were less likely to go higher. Individuals with skin lesions were more likely to go to higher intensity, even though none of the independent variables was significant. Conclusions: The staining intensity was higher in CSCC than in OSCC. A lot of factors are associated with the prognosis of SCCs, and cyclin D1 may be used as a prognostic marker.

Introduction: Recall and precision are two indicators for evaluating information retrieval system’s efficiency and performance. The aim of the present study was to compare the recall and precision of Iranmedex, Magiran and SID DATABASEs for retrieval of scholarly information in the domain of pharmacy.Methods: This work is an analytical study that, in this was used from comparison method and direct observation by end user. The population was articles retrieved from the Web sites of Iranmedex, Magiran & SID DATABASEs. Data collection tool was checklist that validity was confirmed by experts of LIS. First, Keywords were listed from two numbers 7 & 8 of Twenty-first volume Journal of Behavioral pharmacology; And Keywords associated with this field were determined by Pharmacy specialists. Ten selected keywords searched in 3 DATABASEs. Then retrieved results were refer to Pharmacy specialists for identify relevant records. The obtained data were analyzed with descriptive statistics (frequency), (χ2) and SPSS 11.5 software at the significant level of P<0.05.Results: Retrieved records of Iranmedex DATABASE were 615, from Magiran 375 and SID was 116 records. Iranmedex dominated the top positions when comparing relative recall (39%) and SID revealed reliable precision in the output (55.1%). Iranmedex and Magiran DATABASE have had more overlap (219 records).Conclusion: The results are tips for Pharmacy specialists to choose DATABASE for retrieval of scholarly information, if recall is important for they, choose Iranmedex and if high precision is important, need to use the SID DATABASE.